TNFSF11 (DMC267) IgG1 Chimeric mAb

Name: TNFSF11 (DMC267) IgG1 Chimeric mAb
SKU: 28175
Price: 565.00 USD
Availability: InStock

$565.00

Cat.#: 28175

Product Name: Anti-TNFSF11(DMC267) IgG1 Chimeric Monoclonal Antibody

Synonyms: CD254; hRANKL2; ODF; OPGL; OPTB2; RANKL; sOdf; TNLG6B; TRANCE

Description: Anti-TNFSF11 antibody(DMC267) IgG1 Chimeric Monoclonal Antibody

Background: This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT:PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6; which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes; and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.

Applications: Flow Cyt

Recommended Dilutions: Flow Cyt 1:100

Host Species: Rabbit

Isotype: Rabbit:Human Fc chimeric IgG1

Purification: Purified from cell culture supernatant by affinity chromatography

Species Reactivity: Human TNFSF11

Constituents: Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.

Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. Flow cytometry analysis with Anti-TNFSF11 (DMC267) on Expi293 cells transfected with human TNFSF11 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).

SKU: 28175

Category: Dimabio, Rabbit Monoclonal Antibodies, T, Transmembrane Rabbit Monoclonal Antibodies