CSF1R (DM107) Rabbit mAb

Name: CSF1R (DM107) Rabbit mAb
SKU: 28452
Price: 565.00 USD
Availability: InStock

$565.00

Cat.#: 28452

Product Name: Anti-CSF1R(DM107) Rabbit Monoclonal Antibody

Synonyms: CSF1R;C-FMS;CD115;CSFR;FIM2;FMS;M-CSFR

Description: Anti-CSF1R antibody(DM107) Rabbit Monoclonal Antibody

Background: The protein encoded by this gene is the receptor for colony stimulating factor 1; a cytokine which controls the production; differentiation; and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1:PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL); HL cell lines and anaplastic large cell lymphoma.

Applications: ELISA; Flow Cyt

Recommended Dilutions: ELISA 1:5000-10000; Flow Cyt 1:100

Host Species: Rabbit

Isotype: Rabbit IgG

Purification: Purified from cell culture supernatant by affinity chromatography

Species Reactivity: Human CSF1R

Constituents: Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.

Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

Figure 1. ELISA plate pre-coated by 2 µg/ml (100 µl/well) Human CSF1R protein,His tagged protein 11190 can bind Rabbit anti- CSF1R monoclonal antibody (clone: DM107) in a linear range of 0.6-40 ng/ml.

Figure 2. Flow cytometry analysis with Anti-CSF1R (DM107) on Expi293 cells transfected with human CSF1R(Blue histogram)or Expi293 transfected with irrelevant protein(Red histogram).