Biotinylated Anti-CD33 (DM77) Rabbit mAb

Name: Biotinylated Anti-CD33 (DM77) Rabbit mAb
SKU: 28396
Price: 779.00 USD
Availability: InStock

$779.00

Cat.#: 28396

Product Name: Biotinylated Anti-CD33(DM77) Rabbit Monoclonal Antibody

Synonyms: CD33;SIGLEC3;gp67

Description: Biotinylated Anti-CD33 antibody(DM77) Rabbit Monoclonal Antibody

Background: Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans. Upon engagement of ligands such as C1q or syalylated glycoproteins; two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK. These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6:SHP-1 and PTPN11:SHP-2. In turn; these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules. One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase:PI3K.

Applications: ELISA; Flow Cyt

Recommended Dilutions: ELISA 1:5000-10000; Flow Cyt 1:100

Host Species: Rabbit

Isotype: Rabbit IgG

Purification: Purified from cell culture supernatant by affinity chromatography

Species Reactivity: Human CD33

Constituents: Lyophilized from sterile PBS, pH 7.4. 5 % – 8% trehalose is added as protectants before lyophilization.

Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

SKU: 28396

Category: B, CD33, Dimabio, Rabbit Monoclonal Antibodies, Transmembrane Rabbit Monoclonal Antibodies