CTCBIOPSY® A10 Product Feature

Easy Operation:

-- High automation, 10 mins to complete CTC capture and enrichment of 5ml of whole blood.

-- Nano-microscreen technology, no reliance on specific cell marker, suitable for all types of tumors.

Exclusive CTM:

-- No lysis of red blood cells or pre-centrifugation to preserve the CTM intact, direct observation under a
microscope.

-- Pioneer in accurate classification of CTM in China, screen patients containing neutrophil CTM with the
highest risk of metastasis.

Adequate Data:

-- The first CTC device certified by NMPA in 2015, with international patent.

-- Over 30,000 clinical samples' validation in over 100 Grade-A tertiary hospitals in China.

-- Autonomous downstream analyses, such as IF, IHC, FISH and sequencing to meet the requirements of clinical
research.

Superior Performance of CTC-BIOPSY®-A10

Optimized isolation technology by size of epithelial tumor cells (ISET) can accurately and reliably capture
abnormal cells in blood, providing an efficient solution for tumor screening.

Automated Device

High-precision peristaltic pump with negative pressure

High-precision pressure sensor

Automatic control and simulation

Easy Operation

Friendly operation interface

Sorting of samples with one click

Real-time display of blood sample processing

Authoritative Identification

Norms for identification of cell morphology

formulated by authoritative pathology experts

Quick Separation

No reliance on cell marker for separation

Single sample isolation time <10 mins

CTC-BIOPSY®-A10 Patented ISET Technology

Basic principle: ISET technology uses the size and deformability of tumor cells to achieve separation, then use
cell morphology for identification.

With good light transmission, second-generation nano polymer material is resistant to various staining reagents,
allowing direct observation of cells in visible light.

Nano-microsieve technology broke the foreign monopoly, high-precision lithography machine for laser lithography.

13mm micro sieve membrane has 160,000 nano micro sieves with an aperture of 8um to maximize the sorting of blood
cells and tumor cell enrichment.

Uniform hole spacing	Excellent light transmission of membrane
Uniform aperture	Resistance to various staining reagents

CTC-BIOPSY®-High Detection Rate of CTM

CTC detection data of the CTC-BIOPSY® system in 2018-2020 showed an average CTC detection rate for each tumor is
80.90%, CTM (Circulating Tumor Microemboli) detection rate is 12.52%, and the ratio of CTM to total CTC detection
was consistent with study data from Nature in 2019.

Type	Total cases	Detected Qty	Detection rate	Mean	Median
CTC	9304	7527	80.90%	5.154	3
CTM		1165	12.52%	0.7813	0
CTCs		7686	82.61%	16.42	3

CTC-BIOPSY®-Accurate Classification of CTM

CTC neutrophil clusters, representing a critical weakness in the metastatic process, the link between neutrophils
and CTC drives the progress of cell cycle in the blood flow and expands the metastatic potential of CTC.

CTCBIOPSY® is the only NMPA approved detection system in China, it can efficiently capture CTMs containing
neutrophils, which can be seen directly with the eye under ordinary optical microscopes. Patients with a higher
risk of metastasis can be accurately screened for clinical diagnosis and treatment.

CTCBIOPSY® Systematically Detect CTM Containing Neutrophils:

CTCBIOPSY® A10 Product Feature

Easy Operation:

Exclusive CTM:

Adequate Data:

Superior Performance of CTC-BIOPSY®-A10

Automated Device

High-precision peristaltic pump with negative pressure

High-precision pressure sensor

Automatic control and simulation

Easy Operation

Friendly operation interface

Sorting of samples with one click

Real-time display of blood sample processing

Authoritative Identification

Norms for identification of cell morphology

formulated by authoritative pathology experts

Quick Separation

No reliance on cell marker for separation

Single sample isolation time <10 mins

CTC-BIOPSY®-A10 Patented ISET Technology

Uniform hole spacing

Excellent light transmission of membrane

Uniform aperture

Resistance to various staining reagents

CTC-BIOPSY®-High Detection Rate of CTM

CTC-BIOPSY®-Accurate Classification of CTM

CTC

产品分类

CTC-BIOPSY®-A10 Autoanalyzer System