Human CD130 Protein, hFc Tag
$535.00
| Cat.#: 11595 |
| Product Name: Human CD130 Protein |
| Size : 10 µg, 50 µg and 100 µg |
| Synonyms: CD130;CDW130;GP130;IL-6RB |
| Target: CD130 |
| UNIPROT ID: P40189 |
| Description: Recombinant human CD130 protein with C-terminal human Fc tag |
| Background: The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. |
| Species/Host: HEK293 |
| Molecular Weight: The protein has a predicted molecular mass of 91.19 kDa after removal of the signal peptide. |
| Molecular Characterization: CD130(Glu23-Glu619) hFc(Glu99-Ala330) |
| Purity: The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution: Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. |
| Storage & Shipping: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
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